What Makes It Great
- A blend of organic extracts of Reishi, Shiitake, Maitake, Turkey Tail mushrooms and Chaga
- Made from Certified Organic mushrooms
- Gluten-Free, Non-GMO, Vegan
- Guaranteed >20% Beta-glucans
- No added starch, mycelium, or grain of any kind
- 300mg capsules, 90 pills, 45-90 servings
- Verified for quality at accredited 3rd party labs
- Made in an NSF certified facility in the USA
- Formulated and Designed by Dr. Rob Silver DVM, MS
A Potent Immune Blend
5 Defenders™ is a unique blend of the top immune boosting mushrooms†: Turkey Tail, Reishi, Maitake, Shiitake and wild harvested Chaga.
All organically sourced and extracted to increase the bioavailability of the beneficial compounds like beta-glucans.
Why Beta-Glucans Matter
Beta-glucans are the most abundant and primary active compound found in mushrooms and mycelium.
These complex polysaccharides are where much of the immunological benefits come from which is why it is so important to validate and guarantee beta-glucan content.
A lack of beta-glucans can be attributed to many things like low quality ingredients, improper processing and extraction or the addition of fillers like grains (see alpha-glucans).
All Real Mushrooms products have verified levels of beta-glucans right on the label so you can trust that you're getting the benefits you deserve.
†Ratings based on results of the 2024 ConsumerLab.com Survey of Supplement Users. More information at consumerlab.com/survey.
Why we are rated #1 for quality.
Purity. Potency. History.
From a frustration with a lack of quality and transparency in functional mushroom supplements, Real Mushrooms was born.
Read Our Story Best Mushroom Supplement CompanyIndustry Leaders
Backed by over 40 years of experience, we continue to pioneer functional mushroom supplements supported by scientific research.
Beta-glucans Guaranteed
The beneficial mushroom compounds you want are right on the label.
Zero Grain Fillers
Unlike myceliated grain alternatives, our mushroom extracts contain absolutely NO grains or starch fillers.
Do You Really Know What’s in Your Mushrooms?
Many products that claim to contain mushrooms actually contain none. What they are is the mushroom's root system, known as mycelium, which is grown on grains like rice and oats and this grain cannot be separated from the final product. This residual grain contributes high levels of starch which in turn dilutes the potential for active compounds like beta-glucans.
A 2017 study from Nature on reishi supplements found that 74% of products were inauthentic with 68% containing starch-like polysaccharides (ie. fillers).
ConsumerLab also found similar results in their reishi report and found Real Mushrooms to be their #1 choice.
Loved by Vets Around The World
Frequently Asked Questions
Where are your mushrooms from?
All our mushroom extracts are from the leading supplier of organic mushroom extracts: Nammex. They have over 40 years of mushroom growing experience and were one of the first companies to bring organic medicinal mushroom extracts to North America.
Their ingredients go through rigorous quality control and are tested twice for heavy metals, agricultural chemicals and microbial contamination to ensure they meet all standards for dietary supplements of this nature. All of their extracts are made from certified organic mushrooms (fruiting bodies), organically grown or wildcrafted from deep within mountain regions of China.
Mushrooms used for dietary supplements are seldom grown in North American since it is too expensive. In fact, China is the leading supplier of mushrooms worldwide and supplies over 90% of the world’s mushrooms. It has a rich history of mushroom use as both food and medicine and is the birthplace of mushroom cultivation with shiitake being farmed in the early 1200s. China is one of the only places in the world where you can get 100% organic mushroom (fruiting body) extracts that can be sold at an affordable price.
What is the recommended dosage for my pet?
1 capsule for each 20-40 pounds of body weight daily, or as recommended by your veterinarian.
If your pet is under 20 pounds, you may still give them 1 capsule daily.
Why do the capsules contain other ingredients?
Natural ingredients don’t always flow smoothly through processing equipment and capsule manufacturers need to utilize other ingredients in order to fill capsules. It is common practise for encapsulation facilities to require the use of other ingredients.
We have worked closely with our encapsulation partners to make sure that only what is added is absolutely necessary to create the capsules.
Why do you use mushrooms and not mycelium?
It is extremely important to distinguish the difference between mushrooms and mycelium.
Mushrooms are the "fruit" and reproductive stage of these organisms while the mycelium is the root system or "body" of the fungus.
Mushrooms contain much higher levels of active compounds like beta-glucans and have a very large body of research. They have also been consumed for thousands of years as food and many health benefits have been shown from just mushroom consumption.
Mycelium is commonly grown on a grain substrate and this grain cannot be separate from the mycelium so much of the final product is actually grain with no mushrooms present. This shows up in high amounts of starch and low amounts of active compounds like beta-glucans.
For these reasons, Real Mushrooms only utilizes mushrooms in all of their products with verified levels of the important active compounds like beta-glucans and always guarded against starchy fillers like grain.
What is the breakdown of the 5 Defenders blend?
5 Defenders is a blend of extract powders consisting of:
30% Turkey Tail Mushroom
20% Reishi Mushroom
20% Shiitake Mushroom
20% Maitake Mushroom
10% Chaga
How can 5 Defenders help my pet?
5 Defenders is our signature immune supportive blend, which may have anti-viral properties, may support inflammation, and may also blood sugar regulation.
Shop by Type
20,000+ Reviews
Whether capsules or powders, we've got you covered.
- Choosing a selection results in a full page refresh.
Where are your mushrooms from?
All our mushroom extracts are from the leading supplier of organic mushroom extracts: Nammex. They have over 40 years of mushroom growing experience and were one of the first companies to bring organic medicinal mushroom extracts to North America.
Their ingredients go through rigorous quality control and are tested twice for heavy metals, agricultural chemicals and microbial contamination to ensure they meet all standards for dietary supplements of this nature. All of their extracts are made from certified organic mushrooms (fruiting bodies), organically grown or wildcrafted from deep within mountain regions of China.
Mushrooms used for dietary supplements are seldom grown in North American since it is too expensive. In fact, China is the leading supplier of mushrooms worldwide and supplies over 90% of the world’s mushrooms. It has a rich history of mushroom use as both food and medicine and is the birthplace of mushroom cultivation with shiitake being farmed in the early 1200s. China is one of the only places in the world where you can get 100% organic mushroom (fruiting body) extracts that can be sold at an affordable price.
What is the recommended dosage for my pet?
1 capsule for each 20-40 pounds of body weight daily, or as recommended by your veterinarian.
If your pet is under 20 pounds, you may still give them 1 capsule daily.
Why do the capsules contain other ingredients?
Natural ingredients don’t always flow smoothly through processing equipment and capsule manufacturers need to utilize other ingredients in order to fill capsules. It is common practise for encapsulation facilities to require the use of other ingredients.
We have worked closely with our encapsulation partners to make sure that only what is added is absolutely necessary to create the capsules.
Why do you use mushrooms and not mycelium?
It is extremely important to distinguish the difference between mushrooms and mycelium.
Mushrooms are the "fruit" and reproductive stage of these organisms while the mycelium is the root system or "body" of the fungus.
Mushrooms contain much higher levels of active compounds like beta-glucans and have a very large body of research. They have also been consumed for thousands of years as food and many health benefits have been shown from just mushroom consumption.
Mycelium is commonly grown on a grain substrate and this grain cannot be separate from the mycelium so much of the final product is actually grain with no mushrooms present. This shows up in high amounts of starch and low amounts of active compounds like beta-glucans.
For these reasons, Real Mushrooms only utilizes mushrooms in all of their products with verified levels of the important active compounds like beta-glucans and always guarded against starchy fillers like grain.
What is the breakdown of the 5 Defenders blend?
5 Defenders is a blend of extract powders consisting of:
30% Turkey Tail Mushroom
20% Reishi Mushroom
20% Shiitake Mushroom
20% Maitake Mushroom
10% Chaga
How can 5 Defenders help my pet?
5 Defenders is our signature immune supportive blend, which may have anti-viral properties, may support inflammation, and may also blood sugar regulation.
Shop by Type
20,000+ Reviews
Whether capsules or powders, we've got you covered.
- Choosing a selection results in a full page refresh.
What is the recommended dosage for my pet?
1 capsule for each 20-40 pounds of body weight daily, or as recommended by your veterinarian.
If your pet is under 20 pounds, you may still give them 1 capsule daily.
Why do the capsules contain other ingredients?
Natural ingredients don’t always flow smoothly through processing equipment and capsule manufacturers need to utilize other ingredients in order to fill capsules. It is common practise for encapsulation facilities to require the use of other ingredients.
We have worked closely with our encapsulation partners to make sure that only what is added is absolutely necessary to create the capsules.
Why do you use mushrooms and not mycelium?
It is extremely important to distinguish the difference between mushrooms and mycelium.
Mushrooms are the "fruit" and reproductive stage of these organisms while the mycelium is the root system or "body" of the fungus.
Mushrooms contain much higher levels of active compounds like beta-glucans and have a very large body of research. They have also been consumed for thousands of years as food and many health benefits have been shown from just mushroom consumption.
Mycelium is commonly grown on a grain substrate and this grain cannot be separate from the mycelium so much of the final product is actually grain with no mushrooms present. This shows up in high amounts of starch and low amounts of active compounds like beta-glucans.
For these reasons, Real Mushrooms only utilizes mushrooms in all of their products with verified levels of the important active compounds like beta-glucans and always guarded against starchy fillers like grain.
What is the breakdown of the 5 Defenders blend?
5 Defenders is a blend of extract powders consisting of:
30% Turkey Tail Mushroom
20% Reishi Mushroom
20% Shiitake Mushroom
20% Maitake Mushroom
10% Chaga
How can 5 Defenders help my pet?
5 Defenders is our signature immune supportive blend, which may have anti-viral properties, may support inflammation, and may also blood sugar regulation.
Shop by Type
20,000+ Reviews
Whether capsules or powders, we've got you covered.
- Choosing a selection results in a full page refresh.
Why do the capsules contain other ingredients?
Natural ingredients don’t always flow smoothly through processing equipment and capsule manufacturers need to utilize other ingredients in order to fill capsules. It is common practise for encapsulation facilities to require the use of other ingredients.
We have worked closely with our encapsulation partners to make sure that only what is added is absolutely necessary to create the capsules.
Why do you use mushrooms and not mycelium?
It is extremely important to distinguish the difference between mushrooms and mycelium.
Mushrooms are the "fruit" and reproductive stage of these organisms while the mycelium is the root system or "body" of the fungus.
Mushrooms contain much higher levels of active compounds like beta-glucans and have a very large body of research. They have also been consumed for thousands of years as food and many health benefits have been shown from just mushroom consumption.
Mycelium is commonly grown on a grain substrate and this grain cannot be separate from the mycelium so much of the final product is actually grain with no mushrooms present. This shows up in high amounts of starch and low amounts of active compounds like beta-glucans.
For these reasons, Real Mushrooms only utilizes mushrooms in all of their products with verified levels of the important active compounds like beta-glucans and always guarded against starchy fillers like grain.
What is the breakdown of the 5 Defenders blend?
5 Defenders is a blend of extract powders consisting of:
30% Turkey Tail Mushroom
20% Reishi Mushroom
20% Shiitake Mushroom
20% Maitake Mushroom
10% Chaga
How can 5 Defenders help my pet?
5 Defenders is our signature immune supportive blend, which may have anti-viral properties, may support inflammation, and may also blood sugar regulation.
Why do you use mushrooms and not mycelium?
It is extremely important to distinguish the difference between mushrooms and mycelium.
Mushrooms are the "fruit" and reproductive stage of these organisms while the mycelium is the root system or "body" of the fungus.
Mushrooms contain much higher levels of active compounds like beta-glucans and have a very large body of research. They have also been consumed for thousands of years as food and many health benefits have been shown from just mushroom consumption.
Mycelium is commonly grown on a grain substrate and this grain cannot be separate from the mycelium so much of the final product is actually grain with no mushrooms present. This shows up in high amounts of starch and low amounts of active compounds like beta-glucans.
For these reasons, Real Mushrooms only utilizes mushrooms in all of their products with verified levels of the important active compounds like beta-glucans and always guarded against starchy fillers like grain.
What is the breakdown of the 5 Defenders blend?
5 Defenders is a blend of extract powders consisting of:
30% Turkey Tail Mushroom
20% Reishi Mushroom
20% Shiitake Mushroom
20% Maitake Mushroom
10% Chaga
How can 5 Defenders help my pet?
5 Defenders is our signature immune supportive blend, which may have anti-viral properties, may support inflammation, and may also blood sugar regulation.
What is the breakdown of the 5 Defenders blend?
5 Defenders is a blend of extract powders consisting of:
30% Turkey Tail Mushroom
20% Reishi Mushroom
20% Shiitake Mushroom
20% Maitake Mushroom
10% Chaga
How can 5 Defenders help my pet?
5 Defenders is our signature immune supportive blend, which may have anti-viral properties, may support inflammation, and may also blood sugar regulation.
How can 5 Defenders help my pet?
5 Defenders is our signature immune supportive blend, which may have anti-viral properties, may support inflammation, and may also blood sugar regulation.
Shop by Type
20,000+ Reviews
Whether capsules or powders, we've got you covered.